| Tissue Specificity | Brain, mainly in the cerebellum. Expressed densely and selectively in cell bodies of Purkinje cells. |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport.this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable). |
| Protein Name | Excitatory Amino Acid Transporter 4Sodium-Dependent Glutamate/Aspartate TransporterSolute Carrier Family 1 Member 6 |
| Database Links | Reactome: R-HSA-210500Reactome: R-HSA-425393 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Excitatory Amino Acid Transporter 4 antibodyAnti-Sodium-Dependent Glutamate/Aspartate Transporter antibodyAnti-Solute Carrier Family 1 Member 6 antibodyAnti-SLC1A6 antibodyAnti-EAAT4 antibody |
Information sourced from Uniprot.org
