Western blot analysis of extracts of various cell lines, using SLC13A2 antibody (STJ110771) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 10s.

Anti-SLC13A2 antibody (345-455) (STJ110771)

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STJ110771
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC13A2
Gene ID: 9058
Uniprot ID: S13A2_HUMAN
Immunogen Region: 345-455
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 345-455 of human SLC13A2 (NP_003975.1).
Immunogen Sequence: TREPGFFLGWGNLAFPNAKG ESMVSDGTVAIFIGIIMFII PSKFPGLTQDPENPGKLKAP LGLLDWKTVNQKMPWNIVLL LGGGYALAKGSERSGLSEWL GNKLTPLQSVP
Tissue Specificity Expressed in kidney and intestine. In kidney expressed in the proximal tubule (at protein level).
Function Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule. Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic. Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood. Has a critical role in renal dicarboxylate transport.
Protein Name Solute Carrier Family 13 Member 2
Na(+/Dicarboxylate Cotransporter 1
Nadc-1
Renal Sodium/Dicarboxylate Cotransporter
Database Links Reactome: R-HSA-433137
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Solute Carrier Family 13 Member 2 antibody
Anti-Na(+/Dicarboxylate Cotransporter 1 antibody
Anti-Nadc-1 antibody
Anti-Renal Sodium/Dicarboxylate Cotransporter antibody
Anti-SLC13A2 antibody
Anti-NADC1 antibody
Anti-SDCT1 antibody

Information sourced from Uniprot.org

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