| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Mouse/Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SLC12A2 (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | Slc12a2 |
| Gene ID: | 20496 |
| Uniprot ID: | S12A2_MOUSE |
| Immunogen Region: | C-Term |
| Specificity: | Specific for SLC12A2. |
| Immunogen: | A synthetic peptide from c-terminal region of human SLC12A2 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse. |
| Post Translational Modifications | Phosphorylated at Thr-196, Thr-200 and Thr-205 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), promoting its activity. |
| Function | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume. |
| Protein Name | Solute Carrier Family 12 Member 2Basolateral Na-K-Cl SymporterBumetanide-Sensitive Sodium-(Potassium-Chloride Cotransporter 2Bsc2Na-K-2cl Cotransporter 1Mnkcc1 |
| Database Links | Reactome: R-MMU-426117 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Solute Carrier Family 12 Member 2 antibodyAnti-Basolateral Na-K-Cl Symporter antibodyAnti-Bumetanide-Sensitive Sodium-(Potassium-Chloride Cotransporter 2 antibodyAnti-Bsc2 antibodyAnti-Na-K-2cl Cotransporter 1 antibodyAnti-Mnkcc1 antibodyAnti-Slc12a2 antibodyAnti-Nkcc1 antibody |
Information sourced from Uniprot.org