![Anti-SLC10A1 nanobody [SAA1145] (STJN000272)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200885/413067/STJN000272-SDS-PAGE-1__73079.1749232575.jpg?c=1 "Anti-SLC10A1 nanobody [SAA1145] (STJN000272)")
![Anti-SLC10A1 nanobody [SAA1145] (STJN000272)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200885/413067/STJN000272-SDS-PAGE-1__73079.1749232575.jpg?c=1 "Anti-SLC10A1 nanobody [SAA1145] (STJN000272)")
Anti-SLC10A1 nanobody [SAA1145] (STJN000272)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Hepatic Sodium/Bile Acid Cotransporter is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1145 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | SLC10A1 |
| Gene ID | 6554 |
| Uniprot ID | NTCP_HUMAN |
Additional Info
| Function | As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It is strictly dependent on the extracellular presence of sodium. It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate. Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation. (Microbial infection) Acts as an entry receptor for hepatitis B virus (HBV). The recognition for human SLC10A1/NTCP is highly specific. |
| Protein Name | Hepatic Sodium/Bile Acid CotransporterCell Growth-Inhibiting Gene 29 ProteinNa(+/Bile Acid CotransporterNa(+/Taurocholate Transport ProteinSodium/Taurocholate Cotransporting PolypeptideNtcpSolute Carrier Family 10 Member 1Slc10a1 |
| Database Links | Reactome: R-HSA-159418 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Nanobody Names | Anti-Hepatic Sodium/Bile Acid Cotransporter nanobodyAnti-Cell Growth-Inhibiting Gene 29 Protein nanobodyAnti-Na(+/Bile Acid Cotransporter nanobodyAnti-Na(+/Taurocholate Transport Protein nanobodyAnti-Sodium/Taurocholate Cotransporting Polypeptide nanobodyAnti-Ntcp nanobodyAnti-Solute Carrier Family 10 Member 1 nanobodyAnti-Slc10a1 nanobodyAnti-SLC10A1 nanobodyAnti-NTCP nanobodyAnti-GIG29 nanobody |
Information sourced from Uniprot.org