Anti-SLA2 antibody (1-160) (STJ114684)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLA2 (1-160) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLA2 |
| Gene ID | 84174 |
| Uniprot ID | SLAP2_HUMAN |
| Immunogen Region | 1-160 |
| Immunogen Sequence | MGSLPSRRKSLPSPSLSSSV QGQGPVTMEAERSKATAVAL GSFPAGGPAELSLRLGEPLT IVSEDGDWWTVLSEVSGREY NIPSVHVAKVSHGWLYEGLS REKAEELLLLPGNPGGAFLI RESQTRRGSYSLSVRLSRPA SWDRIRHYRIHCLDNGWLYI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SLA2 (NP_115590.1). |
Additional Info
| Tissue Specificity | Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon. |
| Post Translational Modifications | Phosphorylated by CSF1R. |
| Function | Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. |
| Protein Name | Src-Like-Adapter 2Modulator Of Antigen Receptor SignalingMarsSrc-Like Adapter Protein 2Slap-2 |
| Database Links | Reactome: R-HSA-9706369 |
| Cellular Localisation | CytoplasmIsoform 1: Cell MembraneCytoplasmic VesicleLocalized To The Plasma Membrane And Intracellular VesiclesIncluding Late Endosomal VesiclesIsoform 2: CytoplasmMay Be Cytoplasmic And Is Not Localized To Membranes |
| Alternative Antibody Names | Anti-Src-Like-Adapter 2 antibodyAnti-Modulator Of Antigen Receptor Signaling antibodyAnti-Mars antibodyAnti-Src-Like Adapter Protein 2 antibodyAnti-Slap-2 antibodyAnti-SLA2 antibodyAnti-C20orf156 antibodyAnti-SLAP2 antibody |
Information sourced from Uniprot.org