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Anti-SKP1 antibody (41-90 aa) (STJ95675)

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SKP1A/p19 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from COS7 cells, using SKP1A/p19 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of various cells using Skp1 p19 Polyclonal Antibody

Anti-SKP1 antibody (41-90 aa) (STJ95675)

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STJ95675

€57.50 - €282.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse/Rat/Monkey
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-S-phase kinase-associated protein 1 (41-90 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:5000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SKP1
Gene ID:	6500
Uniprot ID:	SKP1_HUMAN
Immunogen Region:	41-90 aa
Specificity:	Skp1 p19 Polyclonal Antibody detects endogenous levels of Skp1 p19 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human SKP1A/p19 at the amino acid range 41-90

Function	Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'.the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.
Protein Name	S-Phase Kinase-Associated Protein 1 Cyclin-A/Cdk2-Associated Protein P19 P19a Organ Of Corti Protein 2 Ocp-2 Organ Of Corti Protein Ii Ocp-Ii Rna Polymerase Ii Elongation Factor-Like Protein Siii Transcription Elongation Factor B Polypeptide 1-Like P19skp1
Database Links	Reactome: R-HSA-1169091 Reactome: R-HSA-1170546 Reactome: R-HSA-174113 Reactome: R-HSA-180534 Reactome: R-HSA-187577 Reactome: R-HSA-195253 Reactome: R-HSA-202424 Reactome: R-HSA-2122947 Reactome: R-HSA-2565942 Reactome: R-HSA-2644606 Reactome: R-HSA-2644607 Reactome: R-HSA-2871837 Reactome: R-HSA-2894862 Reactome: R-HSA-400253 Reactome: R-HSA-5607761 Reactome: R-HSA-5607764 Reactome: R-HSA-5610780 Reactome: R-HSA-5610783 Reactome: R-HSA-5610785 Reactome: R-HSA-5676590 Reactome: R-HSA-5684264 Reactome: R-HSA-68949 Reactome: R-HSA-69231 Reactome: R-HSA-8854050 Reactome: R-HSA-8939902 Reactome: R-HSA-8951664 Reactome: R-HSA-9020702 Reactome: R-HSA-917937 Reactome: R-HSA-9604323 Reactome: R-HSA-9708530 Reactome: R-HSA-9725371 Reactome: R-HSA-9762114 Reactome: R-HSA-983168
Alternative Antibody Names	Anti-S-Phase Kinase-Associated Protein 1 antibody Anti-Cyclin-A/Cdk2-Associated Protein P19 antibody Anti-P19a antibody Anti-Organ Of Corti Protein 2 antibody Anti-Ocp-2 antibody Anti-Organ Of Corti Protein Ii antibody Anti-Ocp-Ii antibody Anti-Rna Polymerase Ii Elongation Factor-Like Protein antibody Anti-Siii antibody Anti-Transcription Elongation Factor B Polypeptide 1-Like antibody Anti-P19skp1 antibody Anti-SKP1 antibody Anti-EMC19 antibody Anti-OCP2 antibody Anti-SKP1A antibody Anti-TCEB1L antibody

Information sourced from Uniprot.org

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