| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SKOR1 (N-Term) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Htr1a |
| Gene ID: | 24473 |
| Uniprot ID: | 5HT1A_RAT |
| Immunogen Region: | N-Term |
| Immunogen: | Synthetic peptide corresponding to amino acids within region 650-700 on human SKOR1 protein. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes. |
| Protein Name | 5-Hydroxytryptamine Receptor 1a 5-Ht-1a 5-Ht1a Serotonin Receptor 1a |
| Database Links | Reactome: R-RNO-390666 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Cell Projection Dendrite |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 1a antibody Anti-5-Ht-1a antibody Anti-5-Ht1a antibody Anti-Serotonin Receptor 1a antibody Anti-Htr1a antibody Anti-5ht1a antibody |
Information sourced from Uniprot.org