| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes. |
| Protein Name | 5-Hydroxytryptamine Receptor 1a5-Ht-1a5-Ht1aSerotonin Receptor 1a |
| Database Links | Reactome: R-RNO-390666 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionDendrite |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 1a antibodyAnti-5-Ht-1a antibodyAnti-5-Ht1a antibodyAnti-Serotonin Receptor 1a antibodyAnti-Htr1a antibodyAnti-5ht1a antibody |
Information sourced from Uniprot.org
