| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SKIC2 |
| Gene ID: |
6499 |
| Uniprot ID: |
SKI2_HUMAN |
| Immunogen Region: |
1-140 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human SKIV2L (NP_008860.4). |
| Immunogen Sequence: |
MMETERLVLPPPDPLDLPLR AVELGCTGHWELLNLPGAPE SSLPHGLPPCAPDLQQEAEQ LFLSSPAWLPLHGVEHSARK WQRKTDPWSLLAVLGAPVPS DLQAQRHPTTGQILGYKEVL LENTNLSATTSLSLRRPPGP |
| Function | Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). |
| Protein Name | Superkiller Complex Protein 2Ski2Helicase-Like ProteinHlp |
| Database Links | Reactome: R-HSA-390471Reactome: R-HSA-429958 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Superkiller Complex Protein 2 antibodyAnti-Ski2 antibodyAnti-Helicase-Like Protein antibodyAnti-Hlp antibodyAnti-SKIC2 antibodyAnti-DDX13 antibodyAnti-SKI2W antibodyAnti-SKIV2 antibodyAnti-SKIV2L antibodyAnti-W antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
