• Immunohistochemistry of baboon kidney with Anti-SIRT5 primary antibody (STJ503038) at 1:50 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-SIRT5 antibody (260-310) (STJ503038)

SKU:
STJ503038-100

£441.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Chicken/Human/Monkey/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SIRT5 (260-310) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.66-0.68 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Sirt5
Gene ID: 306840
Uniprot ID: SIR5_RAT
Immunogen Region: 260-310
Immunogen: Synthetic peptide taken within amino acid region 260-310 on rat Sirtuin 5 protein.
Function NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity.however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
Protein Name Nad-Dependent Protein Deacylase Sirtuin-5 - Mitochondrial
Regulatory Protein Sir2 Homolog 5
Sir2-Like Protein 5
Database Links Reactome: R-RNO-2151201
Cellular Localisation Mitochondrion
Cytoplasm
Cytosol
Nucleus
Mainly Mitochondrial
Also Present Extramitochondrially
With A Fraction Present In The Cytosol And Very Small Amounts Also Detected In The Nucleus
Alternative Antibody Names Anti-Nad-Dependent Protein Deacylase Sirtuin-5 - Mitochondrial antibody
Anti-Regulatory Protein Sir2 Homolog 5 antibody
Anti-Sir2-Like Protein 5 antibody
Anti-Sirt5 antibody

Information sourced from Uniprot.org

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