Anti-SIRP-Alpha 1/Beta 1 antibody (281-330 aa) (STJ97319)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human SIRPA/SIRPB1 at the amino acid range 281-330
General Information
| Short Description | Rabbit polyclonal anti-Tyrosine-protein phosphatase non-receptor type substrate 1 and Signal-regulatory protein beta-1 isoform 3 (281-330 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommend |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SIRPASIRPB1 |
| Gene ID | 14088510326 |
| Uniprot ID | SHPS1_HUMANSIRBL_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human SIRPA/SIRPB1 at the amino acid range 281-330 |
| Immunogen Region | 281-330 aa |
| Specificity | SIRP-Alpha 1/Beta 1 Polyclonal Antibody detects endogenous levels of SIRP-Alpha 1/Beta 1 protein. |
Additional Info
| Post Translational Modifications | N-glycosylated. Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11. |
| Function | Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1Shp Substrate 1Shps-1Brain Ig-Like Molecule With Tyrosine-Based Activation MotifsBitCd172 Antigen-Like Family Member AInhibitory Receptor Shps-1Macrophage Fusion ReceptorMyd-1 AntigenSignal-Regulatory Protein Alpha-1Sirp-Alpha-1Signal-Regulatory Protein Alpha-2Sirp-Alpha-2Signal-Regulatory Protein Alpha-3Sirp-Alpha-3P84Cd Antigen Cd172a |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-391160Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1 antibodyAnti-Shp Substrate 1 antibodyAnti-Shps-1 antibodyAnti-Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs antibodyAnti-Bit antibodyAnti-Cd172 Antigen-Like Family Member A antibodyAnti-Inhibitory Receptor Shps-1 antibodyAnti-Macrophage Fusion Receptor antibodyAnti-Myd-1 Antigen antibodyAnti-Signal-Regulatory Protein Alpha-1 antibodyAnti-Sirp-Alpha-1 antibodyAnti-Signal-Regulatory Protein Alpha-2 antibodyAnti-Sirp-Alpha-2 antibodyAnti-Signal-Regulatory Protein Alpha-3 antibodyAnti-Sirp-Alpha-3 antibodyAnti-P84 antibodyAnti-Cd Antigen Cd172a antibodyAnti-SIRPA antibodyAnti-BIT antibodyAnti-MFR antibodyAnti-MYD1 antibodyAnti-PTPNS1 antibodyAnti-SHPS1 antibodyAnti-SIRP antibody |
Information sourced from Uniprot.org