| Post Translational Modifications | Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2. Phosphorylated at Ser-1349 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome. |
| Function | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis. |
| Protein Name | Signal-Induced Proliferation-Associated 1-Like Protein 1Sipa1-Like Protein 1High-Risk Human Papilloma Viruses E6 Oncoproteins Targeted Protein 1E6-Targeted Protein 1 |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | CytoplasmCytoskeletonPostsynaptic DensitySynapseSynaptosomeAssociated With The Actin CytoskeletonDetected At Synapses And Dendritic Spines Of Cultured Hippocampal Neurons |
| Alternative Antibody Names | Anti-Signal-Induced Proliferation-Associated 1-Like Protein 1 antibodyAnti-Sipa1-Like Protein 1 antibodyAnti-High-Risk Human Papilloma Viruses E6 Oncoproteins Targeted Protein 1 antibodyAnti-E6-Targeted Protein 1 antibodyAnti-SIPA1L1 antibodyAnti-E6TP1 antibodyAnti-KIAA0440 antibody |
Information sourced from Uniprot.org
