| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SIN3A (1-120) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SIN3A |
| Gene ID: |
25942 |
| Uniprot ID: |
SIN3A_HUMAN |
| Immunogen Region: |
1-120 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human Sin3A (NP_056292.1). |
| Immunogen Sequence: |
MKRRLDDQESPVYAAQQRRI PGSTEAFPHQHRVLAPAPPV YEAVSETMQSATGIQYSVTP SYQVSAMPQSSGSHGPAIAA VHSSHHHPTAVQPHGGQVVQ SHAHPAPPVAPVQGQQQFQR |
| Tissue Specificity | Expressed in the developing brain, with highest levels of expression detected in the ventricular zone of various cortical regions. |
| Post Translational Modifications | SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2. |
| Function | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for cortical neuron differentiation and callosal axon elongation. |
| Protein Name | Paired Amphipathic Helix Protein Sin3aHistone Deacetylase Complex Subunit Sin3aTranscriptional Corepressor Sin3a |
| Database Links | Reactome: R-HSA-3899300Reactome: R-HSA-400206Reactome: R-HSA-427413Reactome: R-HSA-8936459Reactome: R-HSA-9022538Reactome: R-HSA-9022692Reactome: R-HSA-9022699Reactome: R-HSA-9022702Reactome: R-HSA-9615017Reactome: R-HSA-9701898Reactome: R-HSA-9707564Reactome: R-HSA-983231 |
| Cellular Localisation | NucleusNucleolusRecruited To The Nucleolus By Sap30l |
| Alternative Antibody Names | Anti-Paired Amphipathic Helix Protein Sin3a antibodyAnti-Histone Deacetylase Complex Subunit Sin3a antibodyAnti-Transcriptional Corepressor Sin3a antibodyAnti-SIN3A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
