| Function | Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex. The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth. |
| Protein Name | Suppressor Of Ikbke 1Suppressor Of Ikk-Epsilon |
| Database Links | Reactome: R-HSA-918233Reactome: R-HSA-933541Reactome: R-HSA-9692916Reactome: R-HSA-9705671 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Suppressor Of Ikbke 1 antibodyAnti-Suppressor Of Ikk-Epsilon antibodyAnti-SIKE1 antibodyAnti-SIKE antibody |
Information sourced from Uniprot.org
