Anti-SIK2 antibody (827-926) (STJ110619)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SIK2 (827-926) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SIK2 |
| Gene ID | 23235 |
| Uniprot ID | SIK2_HUMAN |
| Immunogen Region | 827-926 |
| Immunogen Sequence | PPPPPPRQPGAAPAPLQFSY QTCELPSAASPAPDYPTPCQ YPVDGAQQSDLTGPDCPRSP GLQEAPSSYDPLALSELPGL FDCEMLDAVDPQHNGYVLVN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 827-926 of human SIK2 (NP_056006.1). |
Additional Info
| Post Translational Modifications | Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylated at Thr-484 in response to insulin in adipocytes. Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6. |
| Function | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism. Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity. In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL. Also plays a role in thymic T-cell development. |
| Protein Name | Serine/Threonine-Protein Kinase Sik2Qin-Induced KinaseSalt-Inducible Kinase 2Sik-2Serine/Threonine-Protein Kinase Snf1-Like Kinase 2 |
| Database Links | |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Sik2 antibodyAnti-Qin-Induced Kinase antibodyAnti-Salt-Inducible Kinase 2 antibodyAnti-Sik-2 antibodyAnti-Serine/Threonine-Protein Kinase Snf1-Like Kinase 2 antibodyAnti-SIK2 antibodyAnti-KIAA0781 antibodyAnti-QIK antibodyAnti-SNF1LK2 antibody |
Information sourced from Uniprot.org