Anti-SIGLEC8 antibody [7C9] (STJ16103353)

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STJ16103353-0.1
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Covered by St John's Laboratory Guarantee

Host: Mouse
Applications: FC/ELISA/IP
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal anti-SIGLEC8 for use in FC, ELISA and IP in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : 7C9
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide
Purification: Purified by protein-A affinity chromatography.
Concentration: 1 mg/mL
Storage Instruction: Store at 2-8°C for up to 1-year, upon receipt.
Gene Symbol: SIGLEC8
Gene ID: 27181
Uniprot ID: SIGL8_HUMAN
Immunogen: Extracellular domain of human SIGLEC8 fused with Fc fragment of human IgG1
Function Putative adhesion molecule that mediates sialic-acid dependent binding to blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes.
Protein Name Sialic Acid-Binding Ig-Like Lectin 8
Siglec-8
Sialoadhesin Family Member 2
Saf-2
Database Links Reactome: R-HSA-198933
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Sialic Acid-Binding Ig-Like Lectin 8 antibody
Anti-Siglec-8 antibody
Anti-Sialoadhesin Family Member 2 antibody
Anti-Saf-2 antibody
Anti-SIGLEC8 antibody
Anti-SAF2 antibody

Information sourced from Uniprot.org

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