| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SID1 transmembrane family member 2 (393-443 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SIDT2 |
| Gene ID: | 51092 |
| Uniprot ID: | SIDT2_HUMAN |
| Immunogen Region: | 393-443 aa |
| Specificity: | This antibody detects endogenous levels of SIDT2 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human SIDT2 at the amino acid range 393-443 |
| Function | Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp. |
| Protein Name | Sid1 Transmembrane Family Member 2 |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinCell MembraneMainly Localizes To Lysosomes And Only Partly To The Plasma MembraneLysosomal Localization Is Required For Sidt2-Mediated Intracellular Degradation Of Endogenous Rna |
| Alternative Antibody Names | Anti-Sid1 Transmembrane Family Member 2 antibodyAnti-SIDT2 antibodyAnti-CGI-40 antibodyAnti-PSEC0072 antibodyAnti-UNQ685 antibodyAnti-PRO1325 antibody |
Information sourced from Uniprot.org