| Short Description : | Rabbit polyclonal SIAE (270-450) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SIAE |
| Gene ID: | 54414 |
| Uniprot ID: | SIAE_HUMAN |
| Immunogen Region: | 270-450 |
| Immunogen Sequence: | LKGVVWYQGESNINYNTDLY NCTFPALIEDWRETFHRGSQ GQTERFFPFGLVQLSSDLSK KSSDDGFPQIRWHQTADFGY VPNPKMPNTFMAVAMDLCDR DSPFGSIHPRDKQTVAYRLH LGARALAYGEKNLTFEGPLP EKIELLAHKGLLNLTYYQQI QVQKKDNKIFEISCCSDHRC K |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-450 of human SIAE (NP_733746.1). |
| Tissue Specificity | Widely expressed with high expression in the testis, prostate, and colon. |
| Function | Catalyzes the removal of O-acetyl ester groups from position 9 of the free diacetylated sialate N-acetyl-9-O-acetylneuraminate (Neu5,9Ac2) in the cytosol and of the diacetylated sialate residues of sialylglycoconjugates in the lysosomes (Probable). Together with the sialate-O-acetyltransferase they regulate the balance of acetylated sialoglycoconjugates, key players in various processes such as cell-cell interactions, host-pathogen recognition, and tumor antigenicity. |
| Protein Name | Sialate O-AcetylesteraseSiaeH-LseSialic Acid-Specific 9-O-Acetylesterase |
| Database Links | |
| Cellular Localisation | Isoform 1: LysosomeIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Sialate O-Acetylesterase antibodyAnti-Siae antibodyAnti-H-Lse antibodyAnti-Sialic Acid-Specific 9-O-Acetylesterase antibodyAnti-SIAE antibodyAnti-YSG2 antibody |
Information sourced from Uniprot.org
