| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SHPRH (Internal Region) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 0.02% NaN3 |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Shprh |
| Gene ID: | 268281 |
| Uniprot ID: | SHPRH_MOUSE |
| Immunogen Region: | Internal Region |
| Specificity: | Reacts with an internal region of the mouse SHPRH protein. 95% sequence identity to rat. 90% sequence identity to human |
| Immunogen: | Synthetic peptide corresponding to amino acids from an internal region of mouse SHPRH protein |
| Function | E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. |
| Protein Name | E3 Ubiquitin-Protein Ligase ShprhRing-Type E3 Ubiquitin Transferase ShprhSnf2 - Histone-Linker - Phd And Ring Finger Domain-Containing Helicase |
| Database Links | Reactome: R-MMU-8866654 |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Shprh antibodyAnti-Ring-Type E3 Ubiquitin Transferase Shprh antibodyAnti-Snf2 - Histone-Linker - Phd And Ring Finger Domain-Containing Helicase antibodyAnti-Shprh antibody |
Information sourced from Uniprot.org