• Western blot analysis of various lysates using SHOC2 Rabbit polyclonal antibody (STJ116236) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-SHOC2 antibody (1-280) (STJ116236)

SKU:
STJ116236

£112.50 - £522.50
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Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SHOC2 (1-280) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SHOC2
Gene ID: 8036
Uniprot ID: SHOC2_HUMAN
Immunogen Region: 1-280
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human SHOC2 (NP_031399.2).
Immunogen Sequence: MSSSLGKEKDSKEKDPKVPS AKEREKEAKASGGFGKESKE KEPKTKGKDAKDGKKDSSAA QPGVAFSVDNTIKRPNPAPG TRKKSSNAEVIKELNKCREE NSMRLDLSKRSIHILPSSIK ELTQLTELYLYSNKLQSLPA EVGCLVNLMTLALSENSLTS LPDSLDNLKKLRMLDLRHNK LREIPSVVYRLDSLTTLYLR FNRITTVEKDIKNLSKLSML SIRENKIKQLPAEIGELCN
Function Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
Protein Name Leucine-Rich Repeat Protein Shoc-2
Protein Soc-2 Homolog
Protein Sur-8 Homolog
Database Links Reactome: R-HSA-5673000
Reactome: R-HSA-9726840
Reactome: R-HSA-9726842
Cellular Localisation Cytoplasm
Nucleus
Translocates From Cytoplasm To Nucleus Upon Growth Factor Stimulation
Alternative Antibody Names Anti-Leucine-Rich Repeat Protein Shoc-2 antibody
Anti-Protein Soc-2 Homolog antibody
Anti-Protein Sur-8 Homolog antibody
Anti-SHOC2 antibody
Anti-KIAA0862 antibody

Information sourced from Uniprot.org

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