| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SHOC2 |
| Gene ID: | 8036 |
| Uniprot ID: | SHOC2_HUMAN |
| Immunogen Region: | 1-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human SHOC2 (NP_031399.2). |
| Immunogen Sequence: | MSSSLGKEKDSKEKDPKVPS AKEREKEAKASGGFGKESKE KEPKTKGKDAKDGKKDSSAA QPGVAFSVDNTIKRPNPAPG TRKKSSNAEVIKELNKCREE NSMRLDLSKRSIHILPSSIK ELTQLTELYLYSNKLQSLPA EVGCLVNLMTLALSENSLTS LPDSLDNLKKLRMLDLRHNK LREIPSVVYRLDSLTTLYLR FNRITTVEKDIKNLSKLSML SIRENKIKQLPAEIGELCN |
| Function | Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway. Acts as a scaffolding protein in the SMP complex. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c. |
| Protein Name | Leucine-Rich Repeat Protein Shoc-2Protein Soc-2 HomologProtein Sur-8 Homolog |
| Database Links | Reactome: R-HSA-5673000Reactome: R-HSA-9726840Reactome: R-HSA-9726842 |
| Cellular Localisation | CytoplasmNucleusTranslocates From Cytoplasm To Nucleus Upon Growth Factor Stimulation |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat Protein Shoc-2 antibodyAnti-Protein Soc-2 Homolog antibodyAnti-Protein Sur-8 Homolog antibodyAnti-SHOC2 antibodyAnti-KIAA0862 antibody |
Information sourced from Uniprot.org