| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Serine hydroxymethyltransferase, mitochondrial (122-172 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SHMT2 |
| Gene ID: |
6472 |
| Uniprot ID: |
GLYM_HUMAN |
| Immunogen Region: |
122-172 aa |
| Specificity: |
This antibody detects endogenous levels of GLYM at Human |
| Immunogen: |
Synthesized peptide derived from the human GLYM at the amino acid range 122-172 |
| Function | Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate.5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs. Associates with mitochondrial DNA. In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex. |
| Protein Name | Serine Hydroxymethyltransferase - MitochondrialShmtGlycine HydroxymethyltransferaseSerine Methylase |
| Database Links | Reactome: R-HSA-196757Reactome: R-HSA-9013408 |
| Cellular Localisation | MitochondrionMitochondrion MatrixMitochondrion NucleoidMitochondrion Inner MembraneCytoplasmNucleusMainly Localizes In The MitochondrionAlso Found In The Cytoplasm And Nucleus As Part Of The Brisc Complex |
| Alternative Antibody Names | Anti-Serine Hydroxymethyltransferase - Mitochondrial antibodyAnti-Shmt antibodyAnti-Glycine Hydroxymethyltransferase antibodyAnti-Serine Methylase antibodyAnti-SHMT2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
