Anti-SHKBP1 antibody (STJA0009077)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SHKBP1
General Information
| Short Description | Rabbit polyclonal anti-SH3KBP1-binding protein 1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SHKBP1 |
| Gene ID | 92799 |
| Uniprot ID | SHKB1_HUMAN |
| Immunogen | Synthesized peptide derived from human SHKBP1 |
| Specificity | This antibody detects endogenous levels of SHKBP1 at Human, Mouse, Rat |
Additional Info
| Function | Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. |
| Protein Name | Sh3kbp1-Binding Protein 1Seta-Binding Protein 1 |
| Database Links | Reactome: R-HSA-9013148 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Sh3kbp1-Binding Protein 1 antibodyAnti-Seta-Binding Protein 1 antibodyAnti-SHKBP1 antibodyAnti-SB1 antibodyAnti-PP203 antibody |
Information sourced from Uniprot.org