| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SHANK2 (850-920 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | SHANK2 |
| Gene ID: | 22941 |
| Uniprot ID: | SHAN2_HUMAN |
| Immunogen Region: | 850-920 aa |
| Specificity: | Specific for SHANK2. |
| Immunogen: | A synthetic peptide from aa region 850-920 of human SHANK2 conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 90% identity with mouse and rat sequences. |
| Function | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Protein Name | Sh3 And Multiple Ankyrin Repeat Domains Protein 2Shank2Cortactin-Binding Protein 1Cortbp1Proline-Rich Synapse-Associated Protein 1 |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Apical Cell MembraneCytoplasmSynapsePostsynaptic DensityCell ProjectionGrowth ConeDendritic SpineColocalizes With Cortactin In Growth Cones In Differentiating Hippocampal NeuronsColocalized With Pde4d To The Apical Membrane Of Colonic Crypt Cells |
| Alternative Antibody Names | Anti-Sh3 And Multiple Ankyrin Repeat Domains Protein 2 antibodyAnti-Shank2 antibodyAnti-Cortactin-Binding Protein 1 antibodyAnti-Cortbp1 antibodyAnti-Proline-Rich Synapse-Associated Protein 1 antibodyAnti-SHANK2 antibodyAnti-CORTBP1 antibodyAnti-KIAA1022 antibodyAnti-PROSAP1 antibody |
Information sourced from Uniprot.org