| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-SH3 and multiple ankyrin repeat domains protein 2 (331-380 aa) for use in WB and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SHANK2 |
| Gene ID: | 22941 |
| Uniprot ID: | SHAN2_HUMAN |
| Immunogen Region: | 331-380 aa |
| Specificity: | Shank 2 Polyclonal Antibody detects endogenous levels of Shank 2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human SHANK2 at the amino acid range 331-380 |
| Function | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Protein Name | Sh3 And Multiple Ankyrin Repeat Domains Protein 2Shank2Cortactin-Binding Protein 1Cortbp1Proline-Rich Synapse-Associated Protein 1 |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Apical Cell MembraneCytoplasmSynapsePostsynaptic DensityCell ProjectionGrowth ConeDendritic SpineColocalizes With Cortactin In Growth Cones In Differentiating Hippocampal NeuronsColocalized With Pde4d To The Apical Membrane Of Colonic Crypt Cells |
| Alternative Antibody Names | Anti-Sh3 And Multiple Ankyrin Repeat Domains Protein 2 antibodyAnti-Shank2 antibodyAnti-Cortactin-Binding Protein 1 antibodyAnti-Cortbp1 antibodyAnti-Proline-Rich Synapse-Associated Protein 1 antibodyAnti-SHANK2 antibodyAnti-CORTBP1 antibodyAnti-KIAA1022 antibodyAnti-PROSAP1 antibody |
Information sourced from Uniprot.org
