| Host: |
Mouse |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Shank1 (C-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
M369 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: |
Antigen Affinity Purified |
| Dilution Range: |
WB 1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Shank1 |
| Gene ID: |
78957 |
| Uniprot ID: |
SHAN1_RAT |
| Immunogen Region: |
C-Term |
| Specificity: |
This antibody detects a 225 kDa* protein corresponding to the molecular mass of Shank1 on SDS-PAGE immunoblots of adult mouse brain. |
| Immunogen: |
Clone M369 was generated from a sequence corresponding to amino acids in the C-terminal region of rat Shank1. This sequence has high homology to human and mouse Shank1. |
| Function | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function. |
| Protein Name | Sh3 And Multiple Ankyrin Repeat Domains Protein 1Shank1Gkap/Sapap-Interacting ProteinSpank-1Somatostatin Receptor-Interacting ProteinSstr-Interacting ProteinSstripSynamon |
| Database Links | Reactome: R-RNO-6794361 |
| Cellular Localisation | CytoplasmSynapsePostsynaptic DensityColocalizes With Alpha-Latrotoxin Receptor 1 |
| Alternative Antibody Names | Anti-Sh3 And Multiple Ankyrin Repeat Domains Protein 1 antibodyAnti-Shank1 antibodyAnti-Gkap/Sapap-Interacting Protein antibodyAnti-Spank-1 antibodyAnti-Somatostatin Receptor-Interacting Protein antibodyAnti-Sstr-Interacting Protein antibodyAnti-Sstrip antibodyAnti-Synamon antibodyAnti-Shank1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
