Anti-SH3GL2 antibody (1-270) (STJ27668)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SH3GL2 (1-270) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SH3GL2 |
| Gene ID | 6456 |
| Uniprot ID | SH3G2_HUMAN |
| Immunogen Region | 1-270 |
| Immunogen Sequence | MSVAGLKKQFHKATQKVSEK VGGAEGTKLDDDFKEMERKV DVTSRAVMEIMTKTIEYLQP NPASRAKLSMINTMSKIRGQ EKGPGYPQAEALLAEAMLKF GRELGDDCNFGPALGEVGEA MRELSEVKDSLDIEVKQNFI DPLQNLHDKDLREIQHHLKK LEGRRLDFDYKKKRQGKIPD EELRQALEKFDESKEIAESS MFNLLEMDIEQVSQLSALVQ AQLEYHKQAVQILQQVTVR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human SH3GL2 (NP_003017.1). |
Additional Info
| Tissue Specificity | Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum. |
| Function | Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. |
| Protein Name | Endophilin-A1Een-B1Endophilin-1Sh3 Domain Protein 2aSh3 Domain-Containing Grb2-Like Protein 2 |
| Database Links | Reactome: R-HSA-177504Reactome: R-HSA-182971Reactome: R-HSA-2132295Reactome: R-HSA-432720Reactome: R-HSA-432722Reactome: R-HSA-437239Reactome: R-HSA-6807004Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8875360 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinEarly EndosomePresynapse |
| Alternative Antibody Names | Anti-Endophilin-A1 antibodyAnti-Een-B1 antibodyAnti-Endophilin-1 antibodyAnti-Sh3 Domain Protein 2a antibodyAnti-Sh3 Domain-Containing Grb2-Like Protein 2 antibodyAnti-SH3GL2 antibodyAnti-CNSA2 antibodyAnti-SH3D2A antibody |
Information sourced from Uniprot.org