| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SH2 domain-containing protein 3C is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SH2D3C |
| Gene ID: | 10044 |
| Uniprot ID: | SH2D3_HUMAN |
| Specificity: | SH2D3 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Isoform 1: Phosphorylated by MAPK/ERK upon T-cell receptor stimulation in T-cells. |
| Function | Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response. Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1. Promotes cell migration and invasion through the extracellular matrix. Required for marginal zone B-cell development and thymus-independent type 2 immune responses. Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL. Plays a role in CXCL13-induced chemotaxis of B-cells. Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development. Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons. Isoform 1: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1. Required for tissue-specific adhesion of T lymphocytes to peripheral tissues. Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9. May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells. Isoform 2: May be involved in the BCAR1/CAS-mediated JNK activation pathway. |
| Protein Name | Sh2 Domain-Containing Protein 3c Cas/Hef1-Associated Signal Transducer Chat-H Novel Sh2-Containing Protein 3 Sh2 Domain-Containing Eph Receptor-Binding Protein 1 Shep1 |
| Cellular Localisation | Cytoplasm Cell Membrane Peripheral Membrane Protein Cell Projection Axon Ruffle Membrane Associated With The Membrane When Egf-Stimulated Expressed At The Cortical Actin Ring In B Cells Isoform 1: Cell Membrane |
| Alternative Antibody Names | Anti-Sh2 Domain-Containing Protein 3c antibody Anti-Cas/Hef1-Associated Signal Transducer antibody Anti-Chat-H antibody Anti-Novel Sh2-Containing Protein 3 antibody Anti-Sh2 Domain-Containing Eph Receptor-Binding Protein 1 antibody Anti-Shep1 antibody Anti-SH2D3C antibody Anti-NSP3 antibody Anti-UNQ272 antibody Anti-PRO309 antibody Anti-PRO34088 antibody |
Information sourced from Uniprot.org