Anti-SH2D1A antibody [R09-5F6] (STJA0034852)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human SH2D1A/SAP
General Information
| Short Description | Rabbit monoclonal anti-SH2D1A for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R09-5F6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SH2D1A |
| Gene ID | 4068 |
| Uniprot ID | SH21A_HUMAN |
| Immunogen | A synthetic peptide of human SH2D1A/SAP |
Additional Info
| Tissue Specificity | Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T-lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis. |
| Function | Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. |
| Protein Name | Sh2 Domain-Containing Protein 1aDuncan Disease Sh2-ProteinSignaling Lymphocytic Activation Molecule-Associated ProteinSlam-Associated ProteinT-Cell Signal Transduction Molecule Sap |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Sh2 Domain-Containing Protein 1a antibodyAnti-Duncan Disease Sh2-Protein antibodyAnti-Signaling Lymphocytic Activation Molecule-Associated Protein antibodyAnti-Slam-Associated Protein antibodyAnti-T-Cell Signal Transduction Molecule Sap antibodyAnti-SH2D1A antibodyAnti-DSHP antibodyAnti-SAP antibody |
Information sourced from Uniprot.org