| Post Translational Modifications | Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex. |
| Function | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. |
| Protein Name | Sh2b Adapter Protein 2Adapter Protein With Pleckstrin Homology And Src Homology 2 DomainsSh2 And Ph Domain-Containing Adapter Protein Aps |
| Database Links | Reactome: R-HSA-1433559Reactome: R-HSA-983231 |
| Cellular Localisation | CytoplasmCell MembraneCytoplasmic Before Pdgf StimulationAfter Pdgf StimulationLocalized At The Cell Membrane And Peripheral Region |
| Alternative Antibody Names | Anti-Sh2b Adapter Protein 2 antibodyAnti-Adapter Protein With Pleckstrin Homology And Src Homology 2 Domains antibodyAnti-Sh2 And Ph Domain-Containing Adapter Protein Aps antibodyAnti-SH2B2 antibodyAnti-APS antibody |
Information sourced from Uniprot.org
