| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SH2B adapter protein 2 (Internal) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SH2B2 |
| Gene ID: |
10603 |
| Uniprot ID: |
SH2B2_HUMAN |
| Immunogen Region: |
Internal |
| Specificity: |
APS Polyclonal Antibody detects endogenous levels of APS protein. |
| Immunogen: |
Synthesized peptide derived from the Internal region of human APS. |
| Post Translational Modifications | Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex. |
| Function | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. |
| Protein Name | Sh2b Adapter Protein 2Adapter Protein With Pleckstrin Homology And Src Homology 2 DomainsSh2 And Ph Domain-Containing Adapter Protein Aps |
| Database Links | Reactome: R-HSA-1433559Reactome: R-HSA-983231 |
| Cellular Localisation | CytoplasmCell MembraneCytoplasmic Before Pdgf StimulationAfter Pdgf StimulationLocalized At The Cell Membrane And Peripheral Region |
| Alternative Antibody Names | Anti-Sh2b Adapter Protein 2 antibodyAnti-Adapter Protein With Pleckstrin Homology And Src Homology 2 Domains antibodyAnti-Sh2 And Ph Domain-Containing Adapter Protein Aps antibodyAnti-SH2B2 antibodyAnti-APS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
