| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SGCA |
| Gene ID: | 6442 |
| Uniprot ID: | SGCA_HUMAN |
| Immunogen Region: | 60-290 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-290 of human alpha Sarcoglycan (alpha Sarcoglycan (SGCA) ) (NP_000014.1). |
| Immunogen Sequence: | ITYHAHLQGHPDLPRWLRYT QRSPHHPGFLYGSATPEDRG LQVIEVTAYNRDSFDTTRQR LVLEIGDPEGPLLPYQAEFL VRSHDAEEVLPSTPASRFLS ALGGLWEPGELQLLNVTSAL DRGGRVPLPIEGRKEGVYIK VGSASPFSTCLKMVASPDSH ARCAQGQPPLLSCYDTLAPH FRVDWCNVTLVDKSVPEPAD EVPTPGDGILEHDPFFCPPT EAPDRDFLVDA |
| Tissue Specificity | Most strongly expressed in skeletal muscle. Also expressed in cardiac muscle and, at much lower levels, in lung. In the fetus, most abundant in cardiac muscle and, at lower levels, in lung. Also detected in liver and kidney. Not expressed in brain. |
| Function | Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. |
| Protein Name | Alpha-SarcoglycanAlpha-Sg50 Kda Dystrophin-Associated Glycoprotein50dagAdhalinDystroglycan-2 |
| Cellular Localisation | Cell MembraneSarcolemmaSingle-Pass Type I Membrane ProteinCytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Alpha-Sarcoglycan antibodyAnti-Alpha-Sg antibodyAnti-50 Kda Dystrophin-Associated Glycoprotein antibodyAnti-50dag antibodyAnti-Adhalin antibodyAnti-Dystroglycan-2 antibodyAnti-SGCA antibodyAnti-ADL antibodyAnti-DAG2 antibody |
Information sourced from Uniprot.org