| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:100IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SFRP5 |
| Gene ID: | 6425 |
| Uniprot ID: | SFRP5_HUMAN |
| Immunogen Region: | 30-317 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-317 of human SFRP5 (NP_003006.2). |
| Immunogen Sequence: | EEYDYYGWQAEPLHGRSYSK PPQCLDIPADLPLCHTVGYK RMRLPNLLEHESLAEVKQQA SSWLPLLAKRCHSDTQVFLC SLFAPVCLDRPIYPCRSLCE AVRAGCAPLMEAYGFPWPEM LHCHKFPLDNDLCIAVQFGH LPATAPPVTKICAQCEMEHS ADGLMEQMCSSDFVVKMRIK EIKIENGDRKLIGAQKKKKL LKPGPLKRKDTKRLVLHMKN GAGCPCPQLDSLAGSFLVM |
| Tissue Specificity | Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle. |
| Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina. |
| Protein Name | Secreted Frizzled-Related Protein 5Sfrp-5Frizzled-Related Protein 1bFrp-1bSecreted Apoptosis-Related Protein 3Sarp-3 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Secreted Frizzled-Related Protein 5 antibodyAnti-Sfrp-5 antibodyAnti-Frizzled-Related Protein 1b antibodyAnti-Frp-1b antibodyAnti-Secreted Apoptosis-Related Protein 3 antibodyAnti-Sarp-3 antibodyAnti-SFRP5 antibodyAnti-FRP1B antibodyAnti-SARP3 antibody |
Information sourced from Uniprot.org