• Immunoflourescence of HeLa cells labeled with anti-SAP49 (STJA0003775, red, 1:1000) and anti-vimentin (STJA0003823, green, 1:10,000). The blue is DAPI staining nuclear DNA.
  • Immunofluorescence of HeLa cells showing strong granular nuclear staining of SAP49 (red, 1:1000) and vimentin (STJA0003823, green, 1:10,000). The blue is DAPI staining nuclear DNA.
  • Western blot of HeLa lysate showing specific immunolabeling of the ~49 kDa SAP49 protein.

Anti-SF3B4 antibody (Full Length) [3A1] (STJA0003775)

SKU:
STJA0003775-100

£442.50
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Host: Mouse
Applications: WB/IHC/ICC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-SAP49 (Full Length) is suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry research applications.
Clonality: Monoclonal
Clone ID: 3A1
Conjugation: Unconjugated
Isotype: IgG2b
Formulation: 100 ul in PBS + 50% Glycerol and 5 mm Sodium Azide
Purification: This antibody was protein g purified culture from supernatant.
Dilution Range: WB 1:2000
IHC 1:1000
ICC 1:1000
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SF3B4
Gene ID: 10262
Uniprot ID: SF3B4_HUMAN
Immunogen Region: Full Length
Immunogen: Recombinant full length human SAP49 expressed in and purification from E. Coli.
Function Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
Protein Name Splicing Factor 3b Subunit 4
Pre-Mrna-Splicing Factor Sf3b 49 Kda Subunit
Spliceosome-Associated Protein 49
Sap 49
Database Links Reactome: R-HSA-72163
Reactome: R-HSA-72165
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Splicing Factor 3b Subunit 4 antibody
Anti-Pre-Mrna-Splicing Factor Sf3b 49 Kda Subunit antibody
Anti-Spliceosome-Associated Protein 49 antibody
Anti-Sap 49 antibody
Anti-SF3B4 antibody
Anti-SAP49 antibody

Information sourced from Uniprot.org

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