| Host: |
Rabbit |
| Applications: |
WB/ICC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-SF3B3 (1184-1201 aa) is suitable for use in Western Blot, Immunocytochemistry and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
R07-2K8 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Purification: |
Affinity Purified |
| Concentration: |
0.3 mg/ml |
| Dilution Range: |
WB 1:500-1:1000IF 1:50-1:200 |
| Storage Instruction: |
Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: |
SF3B3 |
| Gene ID: |
23450 |
| Uniprot ID: |
SF3B3_HUMAN |
| Immunogen Region: |
1184-1201 aa |
| Immunogen: |
A synthetic peptide of human SF3B3 |
| Function | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B3 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs. |
| Protein Name | Splicing Factor 3b Subunit 3Pre-Mrna-Splicing Factor Sf3b 130 Kda SubunitSf3b130Staf130Spliceosome-Associated Protein 130Sap 130 |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72165 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Splicing Factor 3b Subunit 3 antibodyAnti-Pre-Mrna-Splicing Factor Sf3b 130 Kda Subunit antibodyAnti-Sf3b130 antibodyAnti-Staf130 antibodyAnti-Spliceosome-Associated Protein 130 antibodyAnti-Sap 130 antibodyAnti-SF3B3 antibodyAnti-KIAA0017 antibodyAnti-SAP130 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
