| Post Translational Modifications | Methylated. Methylation regulates activity in DNA decatenation. Phosphorylated at Ser-508 by CHEK1 and dephosphorylated by protein phosphatase 2A/PP2A. Phosphorylation at Ser-508 is enhanced by DNA damage and promotes recruitment to damaged DNA. It stimulates DNA repair and impairs replication fork restart. |
| Function | Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining. Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A. |
| Protein Name | Histone-Lysine N-Methyltransferase SetmarSet Domain And Mariner Transposase Fusion ProteinMetnase Includes - Histone-Lysine N-Methyltransferase - Transposon Hsmar1 Transposase |
| Cellular Localisation | NucleusChromosomeRecruited On Damaged Dna At Sites Of Double-Strand Breaks |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Setmar antibodyAnti-Set Domain And Mariner Transposase Fusion Protein antibodyAnti-Metnase Includes - Histone-Lysine N-Methyltransferase - Transposon Hsmar1 Transposase antibodyAnti-SETMAR antibody |
Information sourced from Uniprot.org
