| Tissue Specificity | Widely expressed. Expressed in pancreatic islets. |
| Function | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the KR-STA-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS. |
| Protein Name | Histone-Lysine N-Methyltransferase Setd7Histone H3-K4 Methyltransferase Setd7H3-K4-Hmtase Setd7Lysine N-Methyltransferase 7Set Domain-Containing Protein 7Set7/9 |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Setd7 antibodyAnti-Histone H3-K4 Methyltransferase Setd7 antibodyAnti-H3-K4-Hmtase Setd7 antibodyAnti-Lysine N-Methyltransferase 7 antibodyAnti-Set Domain-Containing Protein 7 antibodyAnti-Set7/9 antibodyAnti-SETD7 antibodyAnti-KIAA1717 antibodyAnti-KMT7 antibodyAnti-SET7 antibodyAnti-SET9 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and SETD7 knockout (KO) 293T cells, using [KO Validated] SETD7 Rabbit pAb (STJ112026) at 1:1000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 60s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/92100/409178/STJ112026_1__61044.1744895598.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and SETD7 knockout (KO) 293T cells, using [KO Validated] SETD7 Rabbit pAb (STJ112026) at 1:1000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 60s.")
