| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S7MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SETD7 |
| Gene ID: | 80854 |
| Uniprot ID: | SETD7_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SETD7 (Q8WTS6). |
| Immunogen Sequence: | MDSDDEMVEEAVEGHLDDDG LPHGFCTVTYSSTDRFEGNF VHGEKNGRGKFFFFDGSTLE GYYVDDALQGQGVYTYEDGG VLQGTYVDGELNGPAQEYDT |
| Tissue Specificity | Widely expressed. Expressed in pancreatic islets. |
| Function | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the KR-STA-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS. |
| Protein Name | Histone-Lysine N-Methyltransferase Setd7 Histone H3-K4 Methyltransferase Setd7 H3-K4-Hmtase Setd7 Lysine N-Methyltransferase 7 Set Domain-Containing Protein 7 Set7/9 |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | Nucleus Chromosome |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Setd7 antibody Anti-Histone H3-K4 Methyltransferase Setd7 antibody Anti-H3-K4-Hmtase Setd7 antibody Anti-Lysine N-Methyltransferase 7 antibody Anti-Set Domain-Containing Protein 7 antibody Anti-Set7/9 antibody Anti-SETD7 antibody Anti-KIAA1717 antibody Anti-KMT7 antibody Anti-SET7 antibody Anti-SET9 antibody |
Information sourced from Uniprot.org