| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SETD5 (520-740) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SETD5 |
| Gene ID: |
55209 |
| Uniprot ID: |
SETD5_HUMAN |
| Immunogen Region: |
520-740 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 520-740 of human SETD5 (NP_001073986.1). |
| Immunogen Sequence: |
HAFENLEKRKKRRDQPLEQS NSDVEITTTTSETPVGEETK TEAPESEVSNSVSNVTIPST PQSVGVNTRRSSQAGDIAAE KLVPKPPPAKPSRPRPKSRI SRYRTSSAQRLKRQKQANAQ QAELSQAALEEGGSNSLVTP TEAGSLDSSGENRPLTGSDP TVVSITGSHVNRAASKYPKT KKYLVTEWLNDKAEKQECPV ECPLRITTDPTVLATTLNML P |
| Function | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. |
| Protein Name | Histone-Lysine N-Methyltransferase Setd5Set Domain-Containing Protein 5 |
| Cellular Localisation | NucleusChromosomeLocalizes To Active Transcribed Genes |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Setd5 antibodyAnti-Set Domain-Containing Protein 5 antibodyAnti-SETD5 antibodyAnti-KIAA1757 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
