| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SETD5 |
| Gene ID: | 55209 |
| Uniprot ID: | SETD5_HUMAN |
| Immunogen Region: | 520-740 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 520-740 of human SETD5 (NP_001073986.1). |
| Immunogen Sequence: | HAFENLEKRKKRRDQPLEQS NSDVEITTTTSETPVGEETK TEAPESEVSNSVSNVTIPST PQSVGVNTRRSSQAGDIAAE KLVPKPPPAKPSRPRPKSRI SRYRTSSAQRLKRQKQANAQ QAELSQAALEEGGSNSLVTP TEAGSLDSSGENRPLTGSDP TVVSITGSHVNRAASKYPKT KKYLVTEWLNDKAEKQECPV ECPLRITTDPTVLATTLNML P |
| Function | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. |
| Protein Name | Histone-Lysine N-Methyltransferase Setd5Set Domain-Containing Protein 5 |
| Cellular Localisation | NucleusChromosomeLocalizes To Active Transcribed Genes |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Setd5 antibodyAnti-Set Domain-Containing Protein 5 antibodyAnti-SETD5 antibodyAnti-KIAA1757 antibody |
Information sourced from Uniprot.org