| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SETD1B |
| Uniprot ID: | SET1B_HUMAN |
| Immunogen Region: | 1673-1770 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1673-1770 of human SETD1B (NP_001340274.1). |
| Immunogen Sequence: | SEFEEMTILYDIWNGGIDEE DIRFLCVTYERLLQQDNGMD WLNDTLWVYHPSTSLSSAKK KKRDDGIREHVTGCARSEGF YTIDKKDKLRYLNSSRAS |
| Function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis. |
| Protein Name | Histone-Lysine N-Methyltransferase Setd1b Lysine N-Methyltransferase 2g Set Domain-Containing Protein 1b Hset1b |
| Cellular Localisation | Nucleus Nucleus Speckle Chromosome Cytoplasm Localizes To A Largely Non-Overlapping Set Of Euchromatic Nuclear Speckles With Setd1a Suggesting That Setd1a And Set1b Each Bind To A Unique Set Of Target Genes (Probable) Predominantly Nuclear |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Setd1b antibody Anti-Lysine N-Methyltransferase 2g antibody Anti-Set Domain-Containing Protein 1b antibody Anti-Hset1b antibody Anti-SETD1B antibody Anti-KIAA1076 antibody Anti-KMT2G antibody Anti-SET1B antibody |
Information sourced from Uniprot.org