| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-C1 Inactivator (201-500) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SERPING1 |
| Gene ID: |
710 |
| Uniprot ID: |
IC1_HUMAN |
| Immunogen Region: |
201-500 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 201-500 of human SERPING1 (NP_001027466.1). |
| Immunogen Sequence: |
KDFTCVHQALKGFTTKGVTS VSQIFHSPDLAIRDTFVNAS RTLYSSSPRVLSNNSDANLE LINTWVAKNTNNKISRLLDS LPSDTRLVLLNAIYLSAKWK TTFDPKKTRMEPFHFKNSVI KVPMMNSKKYPVAHFIDQTL KAKVGQLQLSHNLSLVILVP QNLKHRLEDMEQALSPSVFK AIMEKLEMSKFQPTLLTLPR IKVTTSQDMLSIMEKLEFFD FSYDLNLCGLTEDPDLQVS |
| Post Translational Modifications | Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor). Can be proteolytically cleaved by E.coli stcE. |
| Function | Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. |
| Protein Name | Plasma Protease C1 InhibitorC1 InhC1inhC1 Esterase InhibitorC1-Inhibiting FactorSerpin G1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-9657689Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Plasma Protease C1 Inhibitor antibodyAnti-C1 Inh antibodyAnti-C1inh antibodyAnti-C1 Esterase Inhibitor antibodyAnti-C1-Inhibiting Factor antibodyAnti-Serpin G1 antibodyAnti-SERPING1 antibodyAnti-C1IN antibodyAnti-C1NH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
