| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SERPINC1 |
| Gene ID: | 462 |
| Uniprot ID: | ANT3_HUMAN |
| Immunogen Region: | 33-259 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-259 of human SERPINC1 (NP_000479.1). |
| Immunogen Sequence: | HGSPVDICTAKPRDIPMNPM CIYRSPEKKATEDEGSEQKI PEATNRRVWELSKANSRFAT TFYQHLADSKNDNDNIFLSP LSISTAFAMTKLGACNDTLQ QLMEVFKFDTISEKTSDQIH FFFAKLNCRLYRKANKSSKL VSANRLFGDKSLTFNETYQD ISELVYGAKLQPLDFKENAE QSRAAINKWVSNKTEGRITD VIPSEAINELTVLVLVNTIY FKGLWKS |
| Tissue Specificity | Found in plasma. |
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
| Function | Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. |
| Protein Name | Antithrombin-IiiAtiiiSerpin C1 |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-140875Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Antithrombin-Iii antibodyAnti-Atiii antibodyAnti-Serpin C1 antibodyAnti-SERPINC1 antibodyAnti-AT3 antibodyAnti-PRO0309 antibody |
Information sourced from Uniprot.org
