| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SERPINC1 (33-259) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SERPINC1 |
| Gene ID: |
462 |
| Uniprot ID: |
ANT3_HUMAN |
| Immunogen Region: |
33-259 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 33-259 of human SERPINC1 (NP_000479.1). |
| Immunogen Sequence: |
HGSPVDICTAKPRDIPMNPM CIYRSPEKKATEDEGSEQKI PEATNRRVWELSKANSRFAT TFYQHLADSKNDNDNIFLSP LSISTAFAMTKLGACNDTLQ QLMEVFKFDTISEKTSDQIH FFFAKLNCRLYRKANKSSKL VSANRLFGDKSLTFNETYQD ISELVYGAKLQPLDFKENAE QSRAAINKWVSNKTEGRITD VIPSEAINELTVLVLVNTIY FKGLWKS |
| Tissue Specificity | Found in plasma. |
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
| Function | Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. |
| Protein Name | Antithrombin-IiiAtiiiSerpin C1 |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-140875Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Antithrombin-Iii antibodyAnti-Atiii antibodyAnti-Serpin C1 antibodyAnti-SERPINC1 antibodyAnti-AT3 antibodyAnti-PRO0309 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
