Anti-SEPTIN8 antibody (64-77 aa) [R05-2C6] (STJA0012586)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Septin 8
General Information
| Short Description | Rabbit monoclonal anti-Septin 8 (64-77 aa) for use in WB and IP in Hamster and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Hamster/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-2C6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4ยฐC short term. Aliquot and store at-20ยฐC long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SEPTIN8 |
| Gene ID | 23176 |
| Uniprot ID | SEPT8_HUMAN |
| Immunogen | A synthetic peptide of human Septin 8 |
| Immunogen Region | 64-77 aa |
Additional Info
| Tissue Specificity | Widely expressed, including in brain, heart and platelets.most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary. |
| Function | Filament-forming cytoskeletal GTPase. May play a role in platelet secretion. Seems to participate in the process of SNARE complex formation in synaptic vesicles. Isoform 4: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. |
| Protein Name | Septin-8 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonSynapseCell ProjectionAxonCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembranePresynapseExpressed In Axons Of Immature NeuronsLocalizes To Synapses In Mature NeuronsIn PlateletsFound In Areas Surrounding Alpha-Granules |
| Alternative Antibody Names | Anti-Septin-8 antibodyAnti-SEPTIN8 antibodyAnti-KIAA0202 antibodyAnti-SEPT8 antibody |
Information sourced from Uniprot.org