| Tissue Specificity | Widely expressed, including in brain, heart and platelets.most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary. |
| Function | Filament-forming cytoskeletal GTPase. May play a role in platelet secretion. Seems to participate in the process of SNARE complex formation in synaptic vesicles. Isoform 4: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. |
| Protein Name | Septin-8 |
| Cellular Localisation | CytoplasmCytoskeletonSynapseCell ProjectionAxonCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembranePresynapseExpressed In Axons Of Immature NeuronsLocalizes To Synapses In Mature NeuronsIn PlateletsFound In Areas Surrounding Alpha-Granules |
| Alternative Antibody Names | Anti-Septin-8 antibodyAnti-SEPTIN8 antibodyAnti-KIAA0202 antibodyAnti-SEPT8 antibody |
Information sourced from Uniprot.org
