| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SEPTIN8 |
| Gene ID: | 23176 |
| Uniprot ID: | SEPT8_HUMAN |
| Immunogen Region: | 348-427 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 348-427 of human Septin 8 (NP_001287728.1). |
| Immunogen Sequence: | NKVKETELELKEKERELHEK FEHLKRVHQEEKRKVEEKRR ELEEETNAFNRRKAAVEALQ SQALHATSQQPLRKDKDKKN |
| Tissue Specificity | Widely expressed, including in brain, heart and platelets.most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary. |
| Function | Filament-forming cytoskeletal GTPase. May play a role in platelet secretion. Seems to participate in the process of SNARE complex formation in synaptic vesicles. Isoform 4: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. |
| Protein Name | Septin-8 |
| Cellular Localisation | Cytoplasm Cytoskeleton Synapse Cell Projection Axon Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Membrane Presynapse Expressed In Axons Of Immature Neurons Localizes To Synapses In Mature Neurons In Platelets Found In Areas Surrounding Alpha-Granules |
| Alternative Antibody Names | Anti-Septin-8 antibody Anti-SEPTIN8 antibody Anti-KIAA0202 antibody Anti-SEPT8 antibody |
Information sourced from Uniprot.org