Western blot analysis of extracts of Rat lung, using Septin 6 antibody (STJ11100949) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-SEPT6 antibody (350-434) (STJ11100949)

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STJ11100949
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SEPTIN6
Gene ID: 23157
Uniprot ID: SEPT6_HUMAN
Immunogen Region: 350-434
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 350-434 of human Septin 6 (NP_055944.2).
Immunogen Sequence: VKEKEAELKEAEKELHEKFD RLKKLHQDEKKKLEDKKKSL DDEVNAFKQRKTAAELLQSQ GSQAGGSQTLKRDKEKKNNP WLCTE
Tissue Specificity Widely expressed.
Function Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation.
Protein Name Septin-6
Cellular Localisation Cytoplasm
Cytoskeleton
Spindle
Chromosome
Centromere
Kinetochore
Cleavage Furrow
Midbody
Cell Projection
Cilium
Flagellum
In Metaphase Cells
Localized Within The Microtubule Spindle
At The Metaphase Plate
In Close Apposition To The Kinetochores Of The Congressed Chromosomes
In Cells Undergoing Cytokinesis
Localized To The Midbody
The Ingressing Cleavage Furrow
And The Central Spindle
Found In The Sperm Annulus
Alternative Antibody Names Anti-Septin-6 antibody
Anti-SEPTIN6 antibody
Anti-KIAA0128 antibody
Anti-SEP2 antibody
Anti-SEPT6 antibody

Information sourced from Uniprot.org

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