| Tissue Specificity | Isoform 1 and isoform 2 are expressed in skeletal muscle, brain, lung and placenta. Isoform 2 is also expressed in heart, diaphragm and stomach. |
| Post Translational Modifications | Isoform 2: N-glycosylated. |
| Function | Isoform 2: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity. Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation. Essential for muscle regeneration and satellite cell maintenance in skeletal muscle. |
| Protein Name | Selenoprotein NSeln |
| Database Links | |
| Cellular Localisation | Isoform 2: Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Selenoprotein N antibodyAnti-Seln antibodyAnti-SELENON antibodyAnti-SELN antibodyAnti-SEPN1 antibody |
Information sourced from Uniprot.org
