Anti-SENP6 antibody (1042-1091 aa) (STJ95605)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human SENP6 at the amino acid range 1042-1091
General Information
| Short Description | Rabbit polyclonal anti-Sentrin-specific protease 6 (1042-1091 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SENP6 |
| Gene ID | 26054 |
| Uniprot ID | SENP6_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human SENP6 at the amino acid range 1042-1091 |
| Immunogen Region | 1042-1091 aa |
| Specificity | SENP6 Polyclonal Antibody detects endogenous levels of SENP6 protein. |
Additional Info
| Function | Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. |
| Protein Name | Sentrin-Specific Protease 6Sumo-1-Specific Protease 1Sentrin/Sumo-Specific Protease Senp6 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Sentrin-Specific Protease 6 antibodyAnti-Sumo-1-Specific Protease 1 antibodyAnti-Sentrin/Sumo-Specific Protease Senp6 antibodyAnti-SENP6 antibodyAnti-KIAA0797 antibodyAnti-SSP1 antibodyAnti-SUSP1 antibodyAnti-FKSG6 antibody |
Information sourced from Uniprot.org