| Tissue Specificity | Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney. |
| Function | Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. |
| Protein Name | Semaphorin-7aCdw108Jmh Blood Group AntigenJohn-Milton-Hargen Human Blood Group AgSemaphorin-K1Sema K1Semaphorin-LSema LCd Antigen Cd108 |
| Database Links | Reactome: R-HSA-416700 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorExtracellular SideDetected In A Punctate Pattern On The Cell Membrane Of Basal And Supra-Basal Skin Keratinocytes |
| Alternative Antibody Names | Anti-Semaphorin-7a antibodyAnti-Cdw108 antibodyAnti-Jmh Blood Group Antigen antibodyAnti-John-Milton-Hargen Human Blood Group Ag antibodyAnti-Semaphorin-K1 antibodyAnti-Sema K1 antibodyAnti-Semaphorin-L antibodyAnti-Sema L antibodyAnti-Cd Antigen Cd108 antibodyAnti-SEMA7A antibodyAnti-CD108 antibodyAnti-SEMAL antibody |
Information sourced from Uniprot.org
