| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | SEMA6D |
| Gene ID: | 80031 |
| Uniprot ID: | SEM6D_HUMAN |
| Immunogen Region: | 20-110 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human SEMA6D (NP_705871.1). |
| Immunogen Sequence: | AVSFPEDDEPLNTVDYHYSR QYPVFRGRPSGNESQHRLDF QLMLKIRDTLYIAGRDQVYT VNLNEMPKTEVIPNKKLTWR SRQQDRENCAM |
| Function | Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis. |
| Protein Name | Semaphorin-6d |
| Database Links | Reactome: R-HSA-416700 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell MembraneIsoform 3: Cell MembraneIsoform 4: Cell MembraneIsoform 5: Cell MembraneIsoform 7: Cytoplasm |
| Alternative Antibody Names | Anti-Semaphorin-6d antibodyAnti-SEMA6D antibodyAnti-KIAA1479 antibody |
Information sourced from Uniprot.org
