| Function | Bifunctional axonal guidance cue regulated by sulfated proteoglycans.attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. |
| Protein Name | Semaphorin-5aSemaphorin-FSema F |
| Database Links | Reactome: R-HSA-416700Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Semaphorin-5a antibodyAnti-Semaphorin-F antibodyAnti-Sema F antibodyAnti-SEMA5A antibodyAnti-SEMAF antibody |
Information sourced from Uniprot.org
