Anti-SELENOS antibody (50-150) (STJ117208)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal VIMP (50-150) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SELENOS |
| Gene ID | 55829 |
| Uniprot ID | SELS_HUMAN |
| Immunogen Region | 50-150 |
| Immunogen Sequence | KLSARLRALRQRQLDRAAAA VEPDVVVKRQEALAAARLKM QEELNAQVEKHKEKLKQLEE EKRRQKIEMWDSMQEGKSYK GNAKKPQEEDSPGPSTSSVL K |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human VIMP (NP_982298.2). |
Additional Info
| Post Translational Modifications | Truncated SELENOS proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC2) and CRL2(KLHDC3) complexes, which recognizes the glycine (Gly) at the C-terminus of truncated SELENOS proteins. Truncated SELENOS proteins produced by failed UGA/Sec decoding are also ubiquitinated by the CRL5(KLHDC1) complex. |
| Function | Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. |
| Protein Name | Selenoprotein SSelsVcp-Interacting Membrane Protein |
| Database Links | Reactome: R-HSA-8866654 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinCytoplasm |
| Alternative Antibody Names | Anti-Selenoprotein S antibodyAnti-Sels antibodyAnti-Vcp-Interacting Membrane Protein antibodyAnti-SELENOS antibodyAnti-SELS antibodyAnti-VIMP antibodyAnti-AD-015 antibodyAnti-SBBI8 antibody |
Information sourced from Uniprot.org